Exchange of GATA Factors Mediates Transitions in Looped Chromatin Organization at a Developmentally Regulated Gene Locus
نویسندگان
چکیده
منابع مشابه
Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus.
Enhancers can regulate designate promoters over long distances by forming chromatin loops. Whether chromatin loops are lost or reconfigured during gene repression is largely unexplored. We examined the chromosome conformation of the Kit gene that is expressed during early erythropoiesis but is downregulated upon cell maturation. Kit expression is controlled by sequential occupancy of two GATA f...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2008
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2007.11.020